Differences in performance on the Wisconsin card sorting test (WCST) between patients with tic related OCD and non-tic related OCD: A preliminary investigation

作者：Gruner Patricia^*; McKay Dean

来源：Journal of Obsessive-Compulsive and Related Disorders, 2013, 2(4): 444-447.

DOI：10.1016/j.jocrd.2013.10.005

• Wisconsin card sorting test
• Subtype
• Endophenotype
• Executive functioning
• Age related decline
• Tics

Executive dysfunction has been implicated in the neurobiology of obsessive-compulsive disorder. Few studies have examined differences between individuals with OCD with or without tics. In this study executive functioning was compared between patients with obsessive-compulsive disorder with and without a history of tics. Participants diagnosed with OCD, with and without tics (n=10 per group) were administered the Wisconsin card sorting test (WCST) along with a measures of symptom severity for OCD, tics and depression. The groups did not differ in demographic variables or depression. Results indicated differences in performance on the WCST. Specifically, patients with past or current tics made more non-perseverative and total errors on the WCST and also demonstrated significantly more difficulty with conceptual level responding as compared to a normative sample, whereas the group without a tic history did not. Our findings, along with supporting evidence from imaging research and clinical trials, suggests that the presence of tics may be a valid means for subtyping individuals with obsessive-compulsive disorder.

• 出版日期2013-10
• 单位上海市精神卫生中心