Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy: potential clinical implications

作者：Inta Dragos; Trusel Massimo; Riva Marco A; Sprengel Rolf; Gass Peter^*

来源：International Journal of Neuropsychopharmacology, 2009, 12(8): 1133-1136.

DOI：10.1017/S1461145709990319

• c-Fos
• depression
• glutamate receptors
• NR2B
• mice

Preclinical and clinical studies have shown that N-methyl-D-aspartate (NMDA) receptor antagonists can exert antidepressant effects. Thus, a single intravenous injection of ketamine, a non-competitive NMDA receptor antagonists, has been recently demonstrated to produce a rapid and relatively sustained antidepressant effect in patients. Therefore, the role of NMDA receptors and their signalling pathways for pathophysiology and therapy of depression are under intense research.

• 出版日期2009-9
• 单位河北医科大学; 上海市精神卫生中心