A study of the Willgerodt-Kindler reaction to obtain thioamides and alpha-ketothioamides under solvent-less conditions

作者：Ernesto Valdez Rojas Jose; Rios Guerra Hulme; Leticia Ramirez Sanchez Alma; Garcia Gonzalez Guadalupe; Alvarez Toledano Cecilio; Guadalupe Lopez Cortes Jose; Toscano Ruben A; Guillermo Penieres Carrillo Jose

来源：Canadian Journal of Chemistry, 2012, 90(7): 567-573.

DOI：10.1139/V2012-030

• Willgerodt-Kindler modification
• alpha-ketothioamides
• solvent-less conditions
• IR energy
• noncatalyst

In this paper, the results obtained in the synthesis of thioamides and alpha-ketothioamides by a modification of the Willgerodt-Kindler reaction, under solvent-free and noncatalyst conditions using IR energy as a source of activation, are presented. The use of IR energy in these reactions has been shown to lead to a mixture of thioamide and alpha-ketothioamide as the main products in most cases, with the latter predominating. The yields of alpha-ketothioamides from most of these reactions are better than those reported previously. To the best of our knowledge, this is the first time that IR energy has been applied to promote the Willgerodt-Kindler reaction.

• 出版日期2012-7