Nickel-Catalyzed sp3 C-H Bond Activation from Decarboxylative Cross-Coupling of α,β-Unsaturated Carboxylic Acids with Amides

作者：Zhang, Jia-Xiang; Wang, Yan-Jing; Wang, Nai-Xing^*; Zhang, Wei; Bai, Cui-Bing; Li, Yi-He; Wen, Jia-Long

来源：Synlett, 2014, 25(11): 1621-1625.

DOI：10.1055/s-0033-1341279

• C-H bonds activation
• nickel
• cross-coupling
• amides
• radical reaction

Nickel-catalyzed functionalization of C(sp(3))-H bonds adjacent to a nitrogen atom in amides through decarboxylative cross-coupling of alpha,beta-unsaturated carboxylic acids is reported. A possible reaction mechanism is proposed that involves radical intermediate species.

• 出版日期2014-7
• 单位中国科学院理化技术研究所; 北京化工大学