A Nutritional Approach to Ameliorate Altered Phospholipid Metabolism in Alzheimer%26apos;s Disease

作者:Hartmann Tobias; van Wijk Nick; Wurtman Richard J; Rikkert Marcel G M Olde; Sijben John W C; Soininen Hilkka; Vellas Bruno; Scheltens Philip*
来源:Journal of Alzheimer's Disease, 2014, 41(3): 715-717.
DOI:10.3233/JAD-141137

摘要

Recently, a biomarker panel of 10 plasma lipids, including 8 phosphatidylcholine species, was identified that could predict phenoconversion from cognitive normal aged adults to amnestic mild cognitive impairment or Alzheimer%26apos;s disease (AD) within 2-3 years with %26gt;90% accuracy. The reduced levels of these plasma phospholipids could reflect altered phospholipid metabolism in the brain and periphery. We show that a 24-week nutritional intervention in drug-naive patients with very mild to mild AD significantly increased 5 of the 7 measured biomarker phosphatidylcholine species. By providing nutrients which normally rate-limit phospholipid synthesis, this nutritional intervention could be useful in asymptomatic subjects with a plasma lipid biomarker profile prognostic of AD.

  • 出版日期2014
  • 单位MIT