科研之友
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摘要
Background: Hypertriglyceridemic waist (HTGW) phenotype is a new indicator for the measurement of visceral obesity, which is closely related to cardiovascular and diabetes diseases. However, there are few studies on the relationship between HTGW phenotype and thyroid hormone. Objective: To explore the correlation between HTGW phenotype and thyroid hormone in women with type 2 diabetes(T2DM). Methods: 308 eligible women with T2DM from the Affiliated Hospital of Southwest Medical University were enrolled during May 2017 to May 2019.They were divided into 4 groups by the normal reference range of waistline(<80 cm) and of triacylglycerol(<1.7 mmol/L): group A(normal waistline and triacylglycerol, n=55), group B(normal waistline but elevated triacylglycerol, n=47), group C(elevated waistline but normal triacylglycerol, n=87), and group D(elevated waistline and triacylglycerol, n=119), and were stratified into 2 groups by the visceral fat area: group Ⅰ(visceral fat area<100 cm2, n=236) and group Ⅱ(visceral fat area≥100 cm2, n=72). Spearman rank correlation analysis was used to estimate the correlation of thyroid hormone with waist circumference, triacylglycerol and HTGW. Multivariate Logistic regression analysis was used to explore the influencing factors of HTGW in women with T2DM. Results: The median waist circumference, triacylglycerol, thyroid stimulating hormone(TSH), free thyroxine(FT4) and free triiodothyronine(FT3) for the participants were 83.0(13.0) cm, 1.80(1.32) mmol/L, 2.09(2.07) mmol/L, 1.23(0.27) mmol/L and 2.37(0.48) mmol/L, respectively. There were 119 HTGW patients and 189 non-HTGW patients.TSH was positively correlated with waist circumference (rs=0.13, P=0.03) and HTGW (rs=0.14, P=0.01). FT4 was negatively correlated with HTGW (rs=-0.17, P=0.02). FT3 was positively correlated with waist circumference (rs=0.13, P=0.02). Multivariate Logistic regression analysis showed that waist circumference 〔OR=1.236, 95%CI(1.139, 1.343)〕, triacylglycerol 〔OR=2.501, 95%CI(1.365, 3.082)〕, low-density lipoprotein〔OR=3.045, 95%CI(1.342, 6.906)〕, and FT4 〔OR=0.226, 95%CI(0.066, 0.782)〕were associated with HTGW in women with T2DM(P<0.05). Conclusion In women with T2DM, HTGW was negatively correlated with FT4 but positively correlated with TSH. FT4 was an influencing factor for HTGW in women with T2DM.
- 出版日期2020
