Antioxidant activity of carboxymethyl (1 -> 3)-beta-D-glucan (from the sclerotium of Poria cocos) sulfate (in vitro)

作者：Wang, Qing; Chen, Sha; Han, Lin; Lian, Mengting; Wen, Zhili; Jiayinaguli, Telieke; Liu, Lina; Sun, Renqiang; Cao, Yu^*

来源：International Journal of Biological Macromolecules, 2014, 69: 229-235.

DOI：10.1016/j.ijbiomac.2014.05.038

• Poria cocos
• Antioxidant activities
• Carboxymethyl (1 -> 3)-beta-D-glucan sulfate
• Synergy effect

(1 -> 3)-beta-D-glucan derived from Poria cocos hardly exhibits bioactivities. To extend its use, three types of (1 -> 3)-beta-D-glucan derivatives, which were sulfated (1 -> 3)-beta-D-glucan (S-P), carboxymethyl (1 -> 3)-beta-D-glucan (CMP) and carboxylmethyl (1 -> 3)-beta-D-glucan sulfate (S-CMP), were synthesized. Potential antioxidant activities of S-P, CMP and S-CMP were evaluated in vitro. The experiments of scavenging abilities of free radicals were carried out, such as 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide anion and hydroxyl. Deeply study of the derivatives' inhibitory effect for lipid peroxidation, DNA oxidative damage, erythrocyte hemolysis, and malondialdehyde (MDA) production were determined. And S-CMP significantly (P< 0.01) increased the antioxidant activity of beta-glucan. These results showed that multiple modifications of polysaccharides may bring the derivatives with excellent properties and various applications.

• 出版日期2014-8
• 单位华中师范大学