An Advanced Tool To Interrogate BRD9

作者:Karim Rezaul M; Schonbrunn Ernst
来源:Journal of Medicinal Chemistry, 2016, 59(10): 4459-4461.
DOI:10.1021/acs.jmedchem.6b00550

摘要

Selective inhibitors of bromodomain-containing protein 9 (BRD9) may have therapeutic potential in the treatment of human malignancies and inflammatory diseases. A selective small molecule inhibitor that is well tolerated and has proper pharmacokinetic properties is required to explore the function of BRD9 in diseases. BI-9564 (2) is a cell permeable and noncytotoxic BRD9 inhibitor provided to the scientific community to explore BRD9 biology and determine its potential as a drug target.

  • 出版日期2016-5-26