Novel Polymer Coupled Lipid Nanoparticle of Paclitaxel with Synergistic Enhanced Efficacy Against Cancer

作者：Singodia D^*; Talegaonkar S; Khar R K; Mishra P R

来源：Journal of Biomedical Nanotechnology, 2011, 7(1): 125-126.

DOI：10.1166/jbn.2011.1233

• Lipid Nanoparticle
• Chitosan
• Synergistically Enhance Efficacy

This study was aimed to develop chitosan coupled lipid nanoparticle (Ch-Ptx-Lip), where immunomodulatory activity of chitosan and chemotherapeutic effect of paclitaxel can synergistically enhance efficacy of this novel drug delivery system. Particle size, zeta potential and % Entrapment Efficiency (%EE) of Ch-Ptx-Lip was found to be 113.3 +/- 4.5 nm (PDI: 0.38), (+)35.7 +/- 2.9 mV and 96.4 +/- 1.8% respectively. Morphological evaluation of these particles by TEM shows circular bilayer structure along with outer polymer layers. Ch-Ptx-Lip showed significantly enhanced cytotoxicity (p < 0.05) compared with marketed formulation (Ptx Solution) and Ptx-Lip when evaluated in-vitro by MTT assay on MCF-7 cell lines. Improved efficacy with lower dose of drug can be a new strategy against cancer with minimum side effects and shorter treatment duration.

• 出版日期2011-2