Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet?

作者：Lugaresi Rebeca; Leme Marco; Painelli Vitor de Salles; Murai Igor Hisashi; Roschel Hamilton; Sapienza Marcelo Tatit; Lancha Junior Antonio Herbert; Gualano Bruno^*

来源：Journal of the International Society of Sports Nutrition, 2013, 10(1): 26.

DOI：10.1186/1550-2783-10-26

• Glomerular filtration rate
• Cr-51-EDTA clearance
• Side effects

Background: The aim of this study was to determine the effects of creatine supplementation on kidney function in resistance-trained individuals ingesting a high-protein diet.
Methods: A randomized, double-blind, placebo-controlled trial was performed. The participants were randomly allocated to receive either creatine (20 g/d for 5 d followed by 5 g/d throughout the trial) or placebo for 12 weeks. All of the participants were engaged in resistance training and consumed a high-protein diet (i.e., >= 1.2 g/Kg/d). Subjects were assessed at baseline (Pre) and after 12 weeks (Post). Glomerular filtration rate was measured by Cr-51-EDTA clearance. Additionally, blood samples and a 24-h urine collection were obtained for other kidney function assessments.
Results: No significant differences were observed for Cr-51-EDTA clearance throughout the trial (Creatine: Pre 101.42 +/- 13.11, Post 108.78 +/- 14.41 mL/min/1.73m(2); Placebo: Pre 103.29 +/- 17.64, Post 106.68 +/- 16.05 mL/min/1.73m(2); group x time interaction: F = 0.21, p = 0.64). Creatinine clearance, serum and urinary urea, electrolytes, proteinuria, and albuminuria remained virtually unchanged.
Conclusions: A 12-week creatine supplementation protocol did not affect kidney function in resistance-trained healthy individuals consuming a high-protein diet; thus reinforcing the safety of this dietary supplement.

• 出版日期2013-5-16