Medical linear accelerator mounted mini-beam collimator: design, fabrication and dosimetric characterization

作者：Cranmer Sargison G^*; Crewson C; Davis W M; Sidhu N P; Kundapur V

来源：Physics in Medicine and Biology, 2015, 60(17): 6991-7005.

DOI：10.1088/0031-9155/60/17/6991

• spatial fractionation
• mini-beam radiation therapy
• linear accelerator
• dosimetry and Monte Carlo simulation

The goal of this work was to design, build and experimentally characterize a linear accelerator mounted mini-beam collimator for use at a nominal 6 MV beam energy. Monte Carlo simulation was used in the design and dosimetric characterization of a compact mini-beam collimator assembly mounted to a medical linear accelerator. After fabrication, experimental mini-beam dose profiles and central axis relative output were measured and the results used to validate the simulation data. The simulation data was then used to establish traceability back to an established dosimetric code of practice. The Monte Carlo simulation work revealed that changes in collimator blade width have a greater influence on the valley-to-peak dose ratio than do changes in blade height. There was good agreement between the modeled and measured profile data, with the exception of small differences on either side of the central peak dose. These differences were found to be systematic across all depths and result from limitations associated with the collimator fabrication. Experimental mini-beam relative output and simulation data agreed to better than +/- 2.0%, which is well within the level of uncertainty required for dosimetric traceability of non-standard field geometries. A mini-beam collimator has now been designed, built and experimentally characterized for use with a commercial linear accelerator operated at a nominal 6 MV beam energy.

• 出版日期2015-9-7
• 单位Saskatoon; Saskatchewan