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摘要
The primary objective of the current work is to estimate the association of ejaculate levels of 20 toxic and essential metals and sperm quality parameters in 148 adult men. Materials: Ejaculate volume, absolute and relative sperm count, sperm motility and vitality were assessed in semen samples of 148 men according to the WHO manual. At the same time, concentration of 20 toxic and essential metals (Al, As, Be, Bi, Cd, Co, Cr, Cu, Fe, Hg, I, Li, Mn, Mo, Ni, Pb, Se, Sn, V, Zn) was estimated in ejaculate samples using inductively coupled plasma mass spectrometry. Results: The results show that the increase in seminal liquid volume was accompanied by a significant 37% decrease in sperm copper content. At the same time, the normalization of the ejaculate volume resulted in a 26, 50, and 31% decrease in seminal Mn, Mo, and Ni concentration, respectively. An increase in sperm count was accompanied with a significant 36% decrease in semen Pb content. At the same time, a significant 25% increase in semen vanadium content was observed after normalization of the relative sperm count. Investigation of sperm motility indicated that this parameter was not significantly associated with semen metal levels. A significant 29% increase in selenium ejaculate levels was associated with an increase in sperm vitality. Correlation analysis revealed direct significant interrelation between sperm quality and seminal cobalt and selenium levels, whereas reverse correlation of the parameters was observed with copper, beryllium and lead levels. Conclusions: i) Selenium is characterized by a positive relationship with sperm count, motility and vitality; ii) Relative sperm count is directly associated with seminal vanadium levels;, iii) Ejaculate cadmium, tin and lead concentrations are negatively interrelated with sperm quality; iv) Present study failed to reveal any significant connection between seminal zinc levels and the sperm parameters analyzed.
- 出版日期2015
- 单位UNESCO
