Antinociception Effect and Mechanism of Ruta graveolens L. in Mice

作者：Park Soo Hyun; Sim Yun Beom; Kim Seon Mi; Lee Jin Koo; Lim Soon Sung; Kim Jin Kyu; Suh Hong Won^*

来源：Journal of the Korean Society for Applied Biological Chemistry, 2010, 53(5): 593-597.

DOI：10.3839/jksabc.2010.091

• alpha(2)-adrenergic receptors
• anti-nociception
• inflammatory pain
• opioidergic receptor
• Ruta graveolens L.

Antinociceptive profiles of Rata graveolens L extract were examined in ICR mice. R. graveolens L extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests and attenuated the writhing numbers in the acetic acid-induced writhing test. Cumulative nociceptive response time for intrathecal (i.t.) injection of substance P (0.7 mu g) was decreased by the extract. Intraperitoneal (i.p.) pretreatment with naloxone (opioid receptor antagonist) or yohimbine (alpha(2)-adrenergic receptor antagonist) attenuated antinociceptive effect induced by the extract in the writhing test. However, methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by the extract in the writhing test. These results suggest that R. graveolens L extract exerts antinociceptive property in various pain models. Furthermore, this antinociceptive effect of R. graveolens L extract may be mediated by opioidergic and alpha(2)-adrenergic receptors, but not by serotonergic receptors.

• 出版日期2010-10