An application of Ag(III) complex chemiluminescence system for the determination of enoxacin in capsule and biological fluid

作者：Chen Peiyun; Sun Hanwen^*

来源：Drug Testing and Analysis, 2010, 2(1-2): 24-27.

DOI：10.1002/dta.104

• chemiluminescence
• Ag(III) complex
• enoxacin
• capsule
• urine
• serum

Ag(III) complex chemiluminescence (CL) system was applied for the determination of enoxacin (ENX). The CL conditions of [Ag(HIO(6))(2)](5-) -H(2)SO(4) ENX systems without any luminescence reagent were investigated and optimized. Under the optimized conditions, the CL intensity was proportional to the concentration of ENX in the range from 6.6 x 10(-5) to 3.3 x 10(-3) g/L. The limit of detection (s/n = 3) was 2.0 x 10(-5) g/L. The recovery of ENX from the spiked pharmaceutical preparations was in the range of 82.9-108% with a relative standard deviation of 1.9-3.0%. For spiked serum and urine samples the recovery of ENX was in the range of 83.7-110% with a relative standard deviation of 1.1-2.8%. The proposed method was applied successfully to the determination of the drug in capsule, serum and urine samples.

• 出版日期2010-2
• 单位河北大学