A macrolactonisation approach to the cembrane carbocycle of bielschowskysin

作者：Yang Eugene G; Sekar Karthik; Lear Martin J^*

来源：Tetrahedron Letters, 2013, 54(33): 4406-4408.

DOI：10.1016/j.tetlet.2013.06.012

• Bielschowskysin
• Acylketene
• Furanocembranoid
• Macrocyclisation
• Sonogashira

By judicious choice of a conformationally constraining unit to predispose cyclisation to a 15-membered ring, we present a straightforward strategy to a cembranolide precursor of bielschowskysin by the Sonogashira coupling of two readily prepared fragments (from D-glucose and L-malic acid) followed by a facile beta-acylketene macrolactonisation reaction.

• 出版日期2013-8-14