Petalonia binghamiae Extract and Its Constituent Fucoxanthin Ameliorate High-Fat Diet-Induced Obesity by Activating AMP-Activated Protein Kinase

作者：Kang Seong Il; Shin Hye Sun; Kim Hyo Min; Yoon Seon A; Kang Seung Woo; Kim Jeong Hwan; Ko Hee Chul; Kim Se Jae^*

来源：Journal of Agricultural and Food Chemistry, 2012, 60(13): 3389-3395.

DOI：10.1021/jf2047652

• Petalonia binghamiae
• fucoxanthin
• 3T3-L1 adipocyte
• high-fat diet-induced obesity
• AMP-activated protein kinase

In this study, we investigated the antiobesity properties of Petalonia binghamiae extract (PBE) in mice in which obesity was induced with a high-fat diet (HFD). PBE administration (150 mg/kg/day) for 70 days decreased body weight gain, adipose tissue weight, and the serum triglyceride level in mice fed a HFD. PBE reduced serum levels of glutamic pyruvic transaminase and glutamic oxaloacetic transaminase as well as the accumulation of lipid droplets in the liver. PBE restored the HFD-induced decrease in phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in epididymal adipose tissue. PBE increased the phosphorylation of AMPK and ACC and decreased the expression of SREBP1c in mature 3T3-L1 adipocytes. In addition, we further explored the active compound responsible for AMPK activation by PBE in 3T3-L1 adipocytes. Fucoxanthin isolated from PBE increased the phosphorylation of AMPK and ACC with increasing LKB1 phosphorylation in mature 3T3-L1 adipocytes. Taken together, these data suggest that PBE (or fucoxanthin) exert improving effects on HFD-induced obesity by promoting beta-oxidation and reducing lipogenesis.

• 出版日期2012-4-4