Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

作者：Liu, Z.; Fluhr, J. W.; Song, S. P.; Sun, Z.; Wang, H.; Shi, Y. J.; Elias, P. M.; Man, M. -Q.^*

来源：Skin Pharmacology and Physiology, 2010, 23(6): 313-319.

DOI：10.1159/000314138

• Stratum corneum
• Hydration
• Epidermal permeability barrier function
• Gender
• Stratum corneum resistance

Previous studies have demonstrated that UVB radiation changes the epidermal permeability barrier and stratum corneum (SC) hydration. It is well known that sun exposure causes erythema, sunburn and melanoma. However, whether daily sun exposure alters SC integrity and epidermal permeability barrier function is largely unknown, especially in Chinese subjects. In the present study, we assess the SC integrity, SC hydration and epidermal permeability barrier function following various doses of sun exposure. A total of 258 subjects (124 males and 134 females) aged 18-50 years were enrolled. A multifunctional skin physiology monitor (Courage & Khazaka MPA5) was used to measure SC hydration and transepidermal water loss (TEWL) on the forearms. In males, basal TEWL was higher with higher doses of sun exposure than with lower doses and control, whereas in females, basal TEWL was higher with lower doses of sun exposure than with higher doses and control. In the group with higher doses of sun exposure, TEWL in females was significantly lower than that in males. The barrier recovery was faster in females than in males in both control and lower-dose groups. In both males and females, barrier recovery was delayed with higher doses of sun exposure. In males, sun exposure did not alter SC hydration, while in females SC hydration was lower with lower doses of sun exposure as compared with control and higher doses of sun exposure. These results demonstrated that sun-induced changes in SC function and SC hydration vary with gender and the extent of sun exposure.

• 出版日期2010
• 单位大连医科大学