Antitumor and Antiplatelet Activity of Alkaloids from Veratrum dahuricum

作者：Tang, Jian; Li, Hui-Liang; Shen, Yun-Heng; Jin, Hui-Zi; Yan, Shi-Kai; Liu, Xiao-Hua; Zeng, Hua-Wu; Liu, Run-Hui; Tan, Ye-Xiong; Zhang, Wei-Dong^*

来源：Phytotherapy Research, 2010, 24(6): 821-826.

DOI：10.1002/ptr.3022

• Veratrum dahuricum
• steroidal alkaloid
• antitumor
• antiplatelet
• hedgehog

Ten steroidal alkaloids cyclopamine, veratramine, jervine, 3, 15-diangyloylgermine, 3-angyloylzygadenine, 3-veratroyl zygadenine, 15-veratroylgermine, germine, veratrosine and pseudojervine - from Veratrum dahuricum, together with the ethanol extract and total alkaloids, were evaluated for their antitumor and antiplatelet activities. Cyclopamine, veratramine and germine significantly inhibited the hedgehog pathway in NIH/3T3 cells. Cyclopamine exerted a potent inhibitory effect against the growth of PANC-1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg-1, respectively. Veratroylgermine was found to produce the strongest inhibition against the platelet aggregation induced by arachidonic acid, with inhibition rate of 92.0% at 100 mu M.

• 出版日期2010-6
• 单位中国人民解放军第二军医大学; 上海交通大学