Anti-tumor Effects of Cationic Hybrid Liposomes against Colon Carcinoma along with Apoptosis in Vitro

作者：Hino Motoki; Ichihara Hideaki; Matsumoto Yoko^*; Ueoka Ryuichi

来源：Biological & Pharmaceutical Bulletin, 2012, 35(11): 2097-2101.

• hybrid liposome
• colon carcinoma
• apoptosis

New-type three-component cationic hybrid liposomes (HLs) composed of dimyristoylphosphatidylcholine (DMPC), polyoxyethylene(21)dodecyl ether (C-12(EO)(21)) and O,O'-ditetradecanoyl-N-(alpha-trimethylammonioacectyl) diethanolamine chloride (2C(14)ECl) were produced. Cationic HLs were smaller and more stable than pure DMPC liposomes. It is noteworthy that cationic HLs could remarkably inhibit the growth of human co on cancer (HCT116) cells along with apoptosis in vitro for the first time in this study.

• 出版日期2012-11