A copper-catalyzed three component reaction of aryl acetylene, sulfonyl azide and enaminone to form iminolactone via 6 electrocyclization

作者：Sun, Jiarui; Cheng, Xiangsheng; Mansaray, John Kamanda; Fei, Weihong; Wan, Jieping^*; Yao, Weijun^*

来源：Chemical communications, 2018, 54(99): 13953-13956.

DOI：10.1039/c8cc06868b

• ONE-POT SYNTHESIS
• INTRAMOLECULAR 2+2 CYCLOADDITION
• C-H AMIDATION
• COPPER(I)-CATALYZED REACTION
• MULTICOMPONENT REACTIONS
• 3-COMPONENT REACTION
• EFFICIENT APPROACH
• CASCADE SYNTHESIS
• KETENIMINE
• CHEMISTRY

We developed a copper-catalyzed three component reaction of aryl acetylene, enaminone and sulfonyl azide to construct iminolactone via a cascade process involving copper-catalyzed alkyne-azide cycloaddition (CuAAC), Michael addition of metalated ketenimine followed by elimination and 6 electrocyclization.

• 出版日期2018-12-25
• 单位江西师范大学; 浙江理工大学