Apoptosis induction with electric pulses - A new approach to cancer therapy with drug free

作者：Tang Liling^*; Yao Chenguo; Sui Caixin

来源：Biochemical and Biophysical Research Communications, 2009, 390(4): 1098-1101.

DOI：10.1016/j.bbrc.2009.10.092

• Electric pulse
• Apoptosis
• Cancer therapy
• Drug free

Electrical pulses have been widely used in biomedical fields, whose applications depend on the parameters such as durations and electric intensity. Conventional electroporation (0.1-1 kV/cm, 100 mu s) has been used in cell fusion, transfection and electrochemotherapy. Recent studies with high-intensity (MV/cm) electric field applications with durations of several tens of nanoseconds can affect intracellular of signal transduction and intracellular structures wit h plasma intact, resulting in an application of intracellular manipulation. The most recent development is the finding that parameters between those two ranges could be used to induce apoptosis of cancer cells. Proposal of apoptosis induction and tumor inhibition has advantages to pursue the treatment of cancer free of cytotoxic drugs.

• 出版日期2009-12-25
• 单位重庆大学