A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

作者：Carpenter, Susan; Aiello, Daniel; Atianand, Maninjay K.; Ricci, Emiliano P.; Gandhi, Pallavi; Hall, Lisa L.; Byron, Meg; Monks, Brian; Henry-Bezy, Meabh; Lawrence, Jeanne B.; O'Neill, Luke A. J.; Moore, Melissa J.; Caffrey, Daniel R.^*; Fitzgerald, Katherine A.

来源：Science, 2013, 341(6147): 789-792.

DOI：10.1126/science.1240925

• IN-VIVO
• EXPRESSION
• REVEALS
• GENOME
• CELLS
• A/B
• TRANSCRIPTOMES
• OSTEOPONTIN
• TRANSLATION
• RESOLUTION

An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional co-regulators, and chromatin-modifying factors. We have identified a long noncoding RNA (lncRNA) that acts as a key regulator of this inflammatory response. Pattern recognition receptors such as the Toll-like receptors induce the expression of numerous lncRNAs. One of these, lincRNA-Cox2, mediates both the activation and repression of distinct classes of immune genes. Transcriptional repression of target genes is dependent on interactions of lincRNA-Cox2 with heterogeneous nuclear ribonucleoprotein A/B and A2/B1. Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response.

• 出版日期2013-8-16