Acute loss of vision during therapy of chronic hepatitis C

作者：Salgado J P^*; Khoramnia R; Maier M M; Lohmann C P; von Mohrenfels C Winkler

来源：Ophthalmologe, 2011, 108(6): 561-564.

DOI：10.1007/s00347-010-2327-0

• Bevacizumab
• Central vein occlusion
• Hepatitis C
• Macular edema
• Pegylated interferon-alpha-2a

A patient undergoing combined therapy of chronic hepatitis C with pegylated interferon-alpha-2a (PEG-IFN-alpha-2a) and ribavirin suddenly developed severe loss of visual acuity. A central vein occlusion with macular edema was found and intravitreal injections of bevacizumab were initiated. Retinal occlusion is a known complication of therapy with pegylated interferon-alpha-2a and ribavirin. An interdisciplinary assessment of patients treated for a chronic hepatitis C as well as an early anti-VEGF administration can be helpful in the therapy of this complication of chronic hepatitis C.

• 出版日期2011-6