Maternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease

作者：Kwon Young Man; Hwang Hye Suk; Lee Jong Seok; Ko Eun Ju; Yoo Si Eun; Kim Min Chul; Lee Yu Na; Kim Ki Hye; Song Jae Min; Lee Sujin; Moore Martin L; Kang Sang Moo^*

来源：Antiviral Research, 2014, 104: 1-6.

DOI：10.1016/j.antiviral.2014.01.008

• Maternal antibodies
• FI-RSV
• Passive immunization
• Vaccine enhanced disease

Maternal immunization of mice with formalin inactivated respiratory syncytial virus (FI-RSV) resulted in the passive transfer of RSV antibodies but not cellular components to the offspring. The offspring born to FI-RSV immunized mothers showed serum RSV neutralizing activity, effectively controlled lung viral loads without vaccine-enhanced disease, did not induce pulmonary eosinophilia, and cytokine producing cells after live RSV infection. Therefore, this study provides evidence that maternal immunization provides an in vivo model in investigating the roles of antibodies independent of cellular components.

• 出版日期2014-4