Anticancer Effect of a Novel 2-Arylidene-4,7-dimethyl indan-1-one Against Human Breast Adenocarcinoma Cell Line by G(2)/M Cell Cycle Arrest

作者：Prasanna R^*; Harish C C

来源：Oncology Research, 2010, 18(10): 461-468.

DOI：10.3727/096504010X12704916124747

• Anticancer activity of synthones
• Synthetic anticancer drugs
• Dimethyl indan-1-one
• Breast cancer

A novel compound 2-arylidene-4,7-dimethyl indan-1-one synthesized was screened for anticancer effect against the human breast adenocarcinoma cell line, MCF-7 An IC50 value of >= 80 mu M, nontoxic to the normal breast cell line HBL-100, showed complete Inhibition of the MCF-7 cells Analysis of mechanisms showed nuclear fragmentation and DNA laddering in gel electrophoresis GSH and GR levels were found to be reduced after the compound treatment Cell cycle analysis using fluorescent cytometry revealed G(2)/M phase arrest, which indicates the compound deserves consideration for further studies against cancer

• 出版日期2010