ALZHEIMER'S DISEASE IN ADULTS WITH DOWN SYNDROME

作者：Zigman Warren B^*; Devenny Darlynne A; Krinsky McHale Sharon J; Jenkins Edmund C; Urv Tiina K; Wegiel Jerzy; Schupf Nicole; Silverman Wayne

来源：INTERNATIONAL REVIEW OF RESEARCH IN MENTAL RETARDATION, VOL 36, ELSEVIER ACADEMIC PRESS INC, 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA, 103-145, 2008.

DOI：10.1016/S0074-7750(08)00004-9

Down syndrome is associated with increased mortality rates due to congenital cardiac defects and leukemia early in life, and with Alzheimer's disease and a tendency toward premature aging later in life. Alzheimer's disease was once considered an inexorable result of growing old with Down syndrome, but recent data indicate that risk does not reach 100%. Although some individuals exhibit signs and symptoms of Alzheimer's disease in their 40s, other individuals have reached the age of 70 without developing dementia. This chapter presents a wealth of data from a longstanding longitudinal study with the overall objective of understanding and recounting the mechanisms responsible for these substantial individual differences.

• 出版日期2008