Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

作者：Sprio Simone; Dapporto Massimiliano; Montesi Monica; Panseri Silvia; Lattanzi Wanda; Pola Enrico; Logroscino Giandomenico; Tampieri Anna

来源：Materials, 2016, 9(9): 763.

DOI：10.3390/ma9090763

• bone cement
• hydroxyapatite
• strontium
• alginate
• in vivo
• osteointegration

The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration.

• 出版日期2016-9