Diminished Parietal Cortex Activity Associated with Poor Motion Direction Discrimination Performance in Schizophrenia

作者：Wang Jun; Brown Ryan; Dobkins Karen R; McDowell Jennifer E; Clementz Brett A^*

来源：Cerebral Cortex, 2010, 20(7): 1749-1755.

DOI：10.1093/cercor/bhp243

• ERP
• motion
• motion processing
• P1
• parietal cortex
• schizophrenia
• smooth pursuit
• visual

The results of multiple investigations indicate visual motion-processing abnormalities in schizophrenia. There is little information, however, about the time course and neural correlates of motion-processing abnormalities among these subjects. For the present study, 13 schizophrenia and 13 healthy subjects performed a simple motion direction discrimination task with peripherally presented moving grating stimuli (5 or 10 deg/s). Dense-array electroencephalography data were collected simultaneously. The goal was to discern whether neural deviations associated with motion-processing abnormalities among schizophrenia patients occur early or late in the visual-processing stream. Schizophrenia patients were worse at judging the direction of motion gratings, had enhanced early neural activity (about 90 ms after stimulus onset), and deficient target detection-related late neural activity over parietal cortex (about 400 ms after stimulus onset). In addition, there was a strong association (accounting for 36% of performance variance) between poor behavioral performance and lower target detection-related brain activity among schizophrenia patients. These findings suggest that abnormalities in later stages of motion-processing mechanisms, perhaps beyond extrastriate cortex, may account for behavioral deviations among schizophrenia subjects.

• 出版日期2010-7