Distribution of serine/threonine kinase SAD-B in mouse peripheral nerve synapse

作者：Hagiwara Akari; Harada Kenu; Hida Yamato; Kitajima Isao; Ohtsuka Toshihisa^*

来源：NeuroReport, 2011, 22(7): 319-325.

DOI：10.1097/WNR.0b013e328346013c

• active zone
• motor end plate
• presynaptic terminal
• spinal cord
• synapse

The serine/threonine kinase SAD regulates neural functions such as axon/dendrite polarization and neurotransmitter release. In the vertebrate central nervous system, SAD-B, a homolog of Caenorhabditis elegans SAD-1, is associated with synaptic vesicles and the active zone cytomatrix in nerve terminals. However, the distribution of SAD-B in the peripheral nervous system remains elusive. Here, we show that SAD-B is specifically localized to neuromuscular junctions. Although the active zone protein bassoon showed a punctated signal indicating its localization to motor end plates, SAD-B shows relatively diffuse localization indicating its association with both the active zone and synaptic vesicles. Therefore, SAD kinase may regulate neurotransmitter release from motor end plates in a similar manner to its regulation of neurotransmitter release in the central nervous system.

• 出版日期2011-5-11