A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines

作者：Liu, Mingxing; Li, Jiarong; Chai, Hongxin; Zhang, Kai; Yang, Deli; Zhang, Qi; Shi, Daxin^*

来源：Beilstein Journal of Organic Chemistry, 2015, 11: 2125-2131.

DOI：10.3762/bjoc.11.229

• four-component
• one-pot
• pyrazolo[3,4-d]pyrimidine
• sodium alkoxide

An efficient one-pot synthesis of pyrazolo[3,4-d]pyrimidine derivatives by the four-component condensation of hydrazines, methylenemalononitriles, aldehydes and alcohols has been developed via two different reaction pathways. The structures of target products were characterized by IR spectroscopy, NMR (H-1 and C-13) spectroscopy and HRMS (ESI) spectrometry. The crystal structure of 4-ethoxy-6-(2-nitrophenyl)-1-phenyl-H-1-pyrazolo[3,4-d]pyrimidine was determined by single crystal X-ray diffraction.

• 出版日期2015-11-6
• 单位北京理工大学