Bladder pain syndrome: validation of simple tests for diagnosis in women with chronic pelvic pain: BRaVADO study protocol

作者：Tirlapur Seema A^*; Priest Lee; Wojdyla Daniel; Khan Khalid S

来源：Reproductive Health, 2013, 10: 61.

DOI：10.1186/1742-4755-10-61

• Bladder pain syndrome
• Chronic pelvic pain
• Consensus panel
• Latent class analysis
• Test validation

Background: Bladder pain syndrome (BPS), a condition with no gold standard diagnosis, comprises of a cluster of signs and symptoms. Bladder filling pain and bladder wall tenderness are two basic clinical features, present in a high number of sufferers. This study will validate the performance of these simple tests for BPS in women with chronic pelvic pain (CPP). %26lt;br%26gt;Methods/design: We will conduct a prospective test validation study amongst women with unexplained CPP presenting to gynaecology outpatient clinics. Two index tests will be performed: patient reported bladder filling pain and bladder wall tenderness on internal pelvic bimanual examination. A final diagnosis of BPS will be made by expert consensus panel. We will assess the rates of index tests in women with CPP; evaluate the correlation between index tests and Pelvic Pain Urgency/Frequency (PUF) questionnaire results; and determine index test sensitivity and specificity using a range of analytical methods. Assuming a 50% prevalence of BPS and an 80% power approximately 152 subjects will be required exclude sensitivity of %26lt; 55% at 70% sensitivity. %26lt;br%26gt;Discussion: The results of this test validation study will be used to identify whether a certain combination of signs and symptoms can accurately diagnose BPS.

• 出版日期2013-12-4