Neuronal Fc gamma receptor I as a novel mediator for IgG immune complex-induced peripheral sensitization

作者：Qu Lintao^*

来源：Neural Regeneration Research, 2012, 7(26): 2075-2079.

DOI：10.3969/j.issn.1673-5374.2012.26.009

• immunoglobulin G
• calcium, immune complex
• Fc gamma receptor
• primary sensory afferents
• pain
• transient receptor potential canonical 3
• dorsal root ganglion
• nonselective cation channel
• voltage-gated calcium channel

Chronic pain often accompanies immune-related diseases with an elevated level of IgG immune complex (IgG-IC) in the serum and/or the affected tissues though the underlying mechanisms are largely unknown. Fc gamma receptors (Fc gamma Rs), known as the receptors for the Fc domain of immunoglobulin G (IgG), are typically expressed on immune cells. A general consensus is that the activation of Fc gamma Rs by IgG-IC in such immune cells induces the release of proinflammatory cytokines from the immune cells, which may contribute to the IgG-IC-mediated peripheral sensitization. In addition to the immune cells, recent studies have revealed that Fc gamma RI, but not Fc gamma RII and Fc gamma RIII, is also expressed in a subpopulation of primary sensory neurons. Moreover, IgG-IC directly excites the primary sensory neurons through neuronal Fc gamma RI. These findings indicate that neuronal Fc gamma RI provides a novel direct linkage between immunoglobulin and primary sensory neurons, which may be a novel target for the treatment of pain in the immune-related disorders. In this review, we summarize the expression pattern, functions, and the associated cellular signaling of Fc gamma Rs in the primary sensory neurons.

• 出版日期2012-9-15