Academic and Nonacademic Laboratories Perform Equally on CIQC Immunohistochemistry Proficiency Testing

作者：Chen Zhongchuan Will; Neufeld Heather; Copete Maria A; Garratt John; Gilks C Blake; Torlakovic Emina E^*

来源：American Journal of Clinical Pathology, 2013, 140(1): 55-60.

DOI：10.1309/AJCPHBL59MWBVYRD

• Academic center
• External quality assessment
• Immunohistochemistry
• Proficiency testing

Objectives: To test whether academic centers (ACs) are more successful than nonacademic centers (NACs) in immunohistochemistry (IHC) external quality assessment challenges in the Canadian Immunohistochemistry Quality Control (CIQC) program.
Methods: Results of 9 CIQC challenges for breast cancer marker (BM) and various non breast cancer marker (NBM) tests were examined. Success rates were compared between AC/NAC laboratories and those located in small or large cities. Performance was also correlated with annual IHC case volumes.
Results: There was no statistically significant difference in performance in any of the comparisons. However, overall performance on BM was significantly better (P < .0001, t test) than on NBM tests regardless of AC/NAC nature or city size. The mean failure rate on NBM was approximately twice that of BM tests.
Conclusion: Our results suggest that recent emphasis on breast hormone IHC quality assurance has led to improved test quality.

• 出版日期2013-7