Apolipoprotein E Gene Polymorphism and Serum Lipid Profile in Saudi Patients with Psoriasis

作者：Al Harthi Fahad; Bin Huraib Ghaleb; Zouman Abdulrahman; Arfin Mi**ahul; Tariq Mohammad; Al Asmari Abdulrahaman^*

来源：Disease Markers, 2014, 2014: 239645.

DOI：10.1155/2014/239645

Background/Aim. Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. However, data is limited to a few ethnicities and no similar study has been performed in middle eastern populations. We investigated this association in Saudi psoriasis patients. Methods. Saudi subjects (294) were genotyped for APOE gene using APOE StripAssay kit. Results. The frequencies of alleles epsilon 2, epsilon 4, and genotypes epsilon 3/epsilon 4 and epsilon 3/epsilon 2 were significantly higher in psoriasis patients compared with those in controls. The frequency of epsilon 3 allele and epsilon 3/epsilon 3 genotype was significantly lower in patients. Other genotypes, epsilon 2/epsilon 4, epsilon 2/epsilon 2, and epsilon 4/epsilon 4, were absent in both groups. The serum cholesterol, triglycerides, and LDL levels were significantly higher in psoriasis patients contrary to HDL level. Patients with APOE epsilon 4 had significantly higher levels of total cholesterol and LDL cholesterol, whereas those with the epsilon 2 had higher HDL cholesterol, and triglycerides. Conclusion. APOE alleles epsilon 2,epsilon 4, and genotypes epsilon 2/epsilon 3 and epsilon 4/epsilon 3 are associated with psoriasis and can be a risk factor while allele epsilon 3 and genotype epsilon 3/epsilon 3 may be protective for psoriasis in Saudis. Results of lipid profile support that psoriasis is one of the independent risk factors for hyperlipidemia and emphasize the need of screening cardiovascular diseases in psoriatic patients.

• 出版日期2014