Molecular Identification of Aspergillus Species Collected for the Transplant-Associated Infection Surveillance Network

作者：Balajee S Arunmozhi^*; Kano Rui; Baddley John W; Moser Stephen A; Marr Kieren A; Alexander Barbara D; Andes David; Kontoyiannis Dimitrios P; Perrone Giancarlo; Peterson Stephen; Brandt Mary E; Pappas Peter G; Chiller Tom

来源：Journal of Clinical Microbiology, 2009, 47(10): 3138-3141.

DOI：10.1128/JCM.01070-09

A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and beta-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.

• 出版日期2009-10