Multimodal Recanalization Therapy in Acute Basilar Artery Occlusion Long-Term Functional Outcome and Quality of Life

作者：Ottomeyer Caroline^*; Zeller Judith; Fesl Gunther; Holtmannspoetter Markus; Opherk Christian; Bender Andreas; Dichgans Martin; Brueckmann Hartmut; Pfefferkorn Thomas

来源：Stroke, 2012, 43(8): 2130-2135.

DOI：10.1161/STROKEAHA.112.651281

• basilar artery occlusion
• health-related quality of life
• intravenous thrombolysis
• mechanical recanalization

Background and Purpose-Multimodal recanalization therapy in patients with acute basilar artery occlusion provides high recanalization rates. A substantial subset of treated patients survives with only minor or moderate functional handicap. However, long-term functional outcome and quality of life in these patients have rarely been systematically analyzed.
Methods-In this monocentric retrospective study, we analyzed mortality, long-term functional outcome (modified Rankin Scale), and quality of life (36-Item Short-Form Health Survey questionnaire) in all consecutive patients who had been treated for acute basilar artery occlusion in our institution between December 2002 and December 2009.
Results-Ninety-one patients (57 male; median age, 65 years; range, 20-89 years) were treated by multimodal recanalization therapy. This included intravenous thrombolysis (n = 32) with consecutive on-demand intra-arterial therapy (n = 23) or intra-arterial therapy alone (n = 59). The overall recanalization rate was 89%. After a median observation time of 4.2 years (range, 0.5-7.4 years), the mortality rate was 59%. Among the 35 survivors, 26 patients (74%) had a good or moderate long-term functional outcome (modified Rankin Scale <= 3). Health-related quality of life was better than that of unselected patients with stroke. Backward stepwise logistic regression identified intravenous thrombolysis (P = 0.002) and female sex (P = 0.001) as predictors of favorable functional long-term outcome (modified Rankin Scale <= 3). Coma at admission (Glasgow Coma Scale <= 8) was associated with poor outcome (modified Rankin Scale >= 4; P=0.036).
Conclusions-Long-term survival is achieved in approximately 40% of patients with basilar artery occlusion treated with multimodal recanalization therapy. Approximately 75% of the survivors have a favorable functional long-term outcome with an acceptable quality of life. (Stroke. 2012; 43: 2130-2135.)

• 出版日期2012-8