An antibacterial cytochalasin derivative from the marine-derived fungus Diaporthaceae sp PSU-SP2/4

作者：Khamthong Nanthaphong; Rukachaisirikul Vatcharin^*; Phongpaichit Souwalak; Preedanon Sita; Sakayaroj Jariya

来源：Phytochemistry Letters, 2014, 10: 5-9.

DOI：10.1016/j.phytol.2014.06.014

• Diaporthaceae sp.
• Marine-derived fungus
• Pentacyclic cytochalasin
• Ethyl trihydroxytridecatrienoate
• Antibacterial activity

A new pentacyclic cytochalasin (diaporthalasin, 1) and a new ethyl trihydroxytridecatrienoate (diaporthacol, 2) together with five known compounds, R-mevalonolactone (4), dothiorelone C (5), (4S, 7S, 13S)-4,7-dihydroxy-1,3-tetradeca-1,5-dienolide (6), 4 beta-acetoxy-9 beta, 10 beta, 15 alpha-trihydroxyprobotrydial (7) and O-methyldihydrobotrydial (8) were isolated from the marine-derived fungus Diaporthaceae sp. PSU-SP2/4. The structures were established by spectroscopic techniques. Compound 1 displayed significant antibacterial activity against both Staphylococcus aureus and methicillin-resistant S. aureus with equal MIC values of 2 mu g/mL.

• 出版日期2014-12