Anti-Obesity Effect of Blumea balsamifera Extract in 3T3-L1 Preadipocytes and Adipocytes

作者：Kubota Hiroaki; Kojima Yuasa Akiko; Morii Risako; Huang Xuedan; Norikura Toshio; Rho Sook Nyung; Matsui Yuasa Isao^*

来源：American Journal of Chinese Medicine, 2009, 37(5): 843-854.

DOI：10.1142/s0192415x09007326

• Blumea balsamifera
• 3T3-L1 Cell
• Glycerol-3-Phosphate Dehydrogenase (GPDH)
• Peroxisome Proliferator-Activated Receptor (PPAR)gamma
• CCAAT Element Binding Protein (C/EBPs)
• Leptin
• Adiponectin

Obesity, the leading metabolic disease in the world. is a serious health problem in industrialized countries. We investigated the anti-obesity effect of Blumea balsamifera extract on adipocyte differentiation of 3T3-L1 preadipocytes and anti-obesity effect of 3T3-L1 adipocytes. We found that treatment with an extract of Blumea balsamifera Suppressed lipid accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity without affecting cell viability in 3T3-L1 preadipocytes and adipocytes. Furthermore, Blumea balsamifera extract brought significant attenuation of expressions of key adipogenic transcription factors, including peroxisome proliferator-activated receptor (PPAR)gamma. CCAAT element binding protein (C/EBPs) and leptin, however, induced up-regulation of adiponectin at the protein level in 3T3-L1 preadipocytes and adipocytes. These results suggest that Blumea balsamifera extract may block adipogenesis, at least in part, by decreasing key adipogenic transcription factors in 3T3-L1 preadipocytes and may have antiatherogenic, anti-inflammatory, and antidiabetic effects through up-regulation of adiponectin in 3T3-L1 adipocytes.

• 出版日期2009