Allele frequencies of PON1 Q192R polymorphism in four populations of India

作者：Mitra Siuli; Khurana Priyanka; Panmei Tabitha; Kshatriya Gautam K^*

来源：Environmental Toxicology and Pharmacology, 2015, 39(3): 1051-1056.

DOI：10.1016/j.etap.2015.03.001

• Organophosphate
• Paraoxonase 1
• Q192R
• genetic
• Allele frequency
• Indian population

The allelic distribution at Paraoxonase 1 (PON1) Q192R polymorphism determines differential sensitivity towards certain organophosphate pesticides. The alleles Q (Glutamine) and R (Arginine) at amino acid position 192 are responsible for the lower and higher activity of the enzyme towards paraoxon respectively, making knowledge of this distribution in different populations vital. This study reports the genotype and allele frequencies of the Gln192Arg polymorphism of PON1 in four populations of India, comprising two caste and two tribal groups hitherto unexamined for this polymorphism. The R allele frequencies in Jat, Meo, Santhal and Zeliangrong populations were found to be 0.47, 0.45, 0.54 and 0.51 respectively. The gene diversity analyses show a high genetic differentiation at this locus indicative of the role of populations' history and other evolutionary forces. A comparison with allele frequencies among 106 populations from different continents showed a concordance with their geographic distribution which will have repercussions in policies targeting pesticide usage.

• 出版日期2015-5