Hidradenocarcinoma showing prominent mucinous and squamous differentiation and associated pagetoid cells

作者：Honda Yumi^*; Tanigawa Hiroki; Harada Miho; Fukushima Satoshi; Masuguchi Shinichi; Ishihara Tsuyoshi; Ihn Hironobu; Iyama Ken ichi

来源：Journal of Cutaneous Pathology, 2013, 40(5): 503-508.

DOI：10.1111/cup.12120

• extramammary Paget%26apos
• s disease
• hidradenocarcinoma
• mucin core protein
• mucinous cell
• pagetoid cell

Herein, we report a 63-year-old man presenting with hidradenocarcinoma showing prominent mucinous and squamous differentiation on his back. The tumor was dermal-based, solid and cystic. Tumor cells with squamous differentiation and with keratin pearl formation were identified predominantly in the superficial dermis, and mucinous cells were identified principally in the cystic lesion in the deep dermis. Interestingly, the additional feature of pagetoid cells was identified in the overlying epidermis. Both the mucinous cells in hidradenocarcinoma and pagetoid cells had intracytoplasmic mucin; however, they had different histopathologic findings and immunophenotypes. Mucinous cells in hidradenocarcinoma had small nuclei and abundant intracytoplasmic mucin presenting goblet cells with low rate of positive immunostaining for p53 and Ki67. In contrast, pagetoid cells had larger nuclei with less intracytoplasmic mucin. Both p53- and Ki67-positive cells were increased in pagetoid cells. Additionally, mucinous cells in hidradenocarcinoma were MUC1(+)/MUC2()/MUC5AC(+)/MUC6(+), but pagetoid cells were MUC1(+; focal)/MUC2()/MUC5AC()/MUC6(+; focal). The derivation of pagetoid cells is unclear; however, the localized small region of pagetoid cells over the hidradenocarcinoma in the present case may suggest a common histogenesis of these two malignant neoplasms.

• 出版日期2013-5