Acute and long-term genotoxicity of deltamethrin to insulin-like growth factors and growth hormone in rainbow trout

作者：Aksakal Ercument^*; Ceyhun Saltuk Bugrahan; Erdogan Orhan; Ekinci Deniz

来源：Comparative Biochemistry and Physiology C-Toxicology & Pharmacology, 2010, 152(4): 451-455.

DOI：10.1016/j.cbpc.2010.07.004

• Deltamethrin
• Growth hormone
• Muscles
• Insulin like growth factors
• Oncorhynchus mykiss
• Gene expression
• Real-time PCR

We report here the acute and long-term influences of deltamethrin on the expression of IGF-I, IGF-II and GH-I in rainbow trout muscles. We treated rainbow trouts with different concentrations of deltamethrin (0.25 mu g/L, 1 mu g/L and 2.5 mu g/L) and observed the alterations in mRNA expression levels of IGF-I, IGF-II and GH-I at different time intervals (at 6th, 12th, 24th, 48th, 72nd hours and 30th day). The mRNA levels significantly decreased with increasing deltamethrin concentrations for acute administration. Interestingly, a significant recovery in GH-I expression was seen after the 72nd hour up to 30th day while no significant differences were observed for IGF-I and IGF-II between the same time intervals. Here we demonstrate that deltamethrin exposure decreases the expression of IGF-I. IGF-II and GH-I in rainbow trout which might cause undesirable outcomes not only in growth, but also in development and reproduction.

• 出版日期2010-11