Protein fold recognition with a two-layer method based on SVM-SA, WP-NN and C4.5 (TLM-SNC)

作者：Zangooei Mohammad Hossein; Jalili Saeed^*

来源：International Journal of Data Mining and Bioinformatics, 2013, 8(2): 203-223.

DOI：10.1504/IJDMB.2013.055507

• protein fold recognition
• Bioinformatics Datamining
• support vector machines
• neural network
• C4.5

The structural knowledge of protein is crucial in understanding its biological role. An effort is made to assign a fold to a given protein in a protein fold recognition problem. A computational Two-Layer Method (TLM) based on the Support Vector Machine (SVM), the Neural Network (NN) and the Decision Tree (C4.5) has been developed in this study for the assignment of a protein sequence to a folding class in SCOP. Prediction accuracy is measured on a dataset and the accuracy of the proposed method is very promising in comparison with other classification methods.

• 出版日期2013