A pilot study of the effect of human breast milk on urinary metabolome analysis in infants

作者：Shoji Hiromichi; Taka Hikari; Kaga Naoko; Ikeda Naho; Kitamura Tomohiro; Miura Yoshiki; Shimizu Toshiaki

来源：Journal of Pediatric Endocrinology & Metabolism, 2017, 30(9): 939-946.

DOI：10.1515/jpem-2017-0179

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background:</jats:title><jats:p>This study aimed to examine the nutritional effect of breast feeding on healthy term infants by using urinary metabolome analysis.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>Urine samples were collected from 19 and 14 infants at 1 and 6 months, respectively. Infants were separated into two groups: the breast-fed group receiving &lt;540 mL/week of their intake from formula (n=13 at 1 month; n=9 at 6 months); and the formula-fed group receiving no breast milk (BM) (n=6 at 1 month; n=5 at 6 months). Urinary metabolome analysis was performed using capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF/MS).</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>A total of 29 metabolites were detected by CE-TOF/MS metabolome analysis in all samples. Urinary excretion of choline metabolites (choline base solution,</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>The type of feeding in early infancy affects choline metabolism, as well as lactate, threonine, and carnosine levels, in healthy term infants. Urinary metabolome analysis by the CE-TOF/MS method is useful for assessing nutritional metabolism in infants.</jats:p></jats:sec>

• 出版日期2017-9