Promyelocytic Leukemia Zinc Finger Protein Regulates Interferon-Mediated Innate Immunity

作者：Xu Dakang; Holko Michelle; Sadler Anthony J; Scott Bernadette; Higashiyama Shigeki; Berkofsky Fessler Windy; McConnell Melanie J; Pandolfi Pier Paolo; Licht Jonathan D; Williams Bryan R G^*

来源：Immunity, 2009, 30(6): 802-816.

DOI：10.1016/j.immuni.2009.04.013

Interferons (IFNs) direct innate and acquired immune responses and, accordingly, are used therapeutically to treat a number of diseases, yet the diverse effects they elicit are not fully understood. Here, we identified the promyelocytic leukemia zinc finger (PLZF) protein as a previously unrecognized component of the IFN response. IFN stimulated an association of PLZF with promyelocytic leukemia protein (PML) and histone deacetylase 1 (HDAC1) to induce a decisive subset of IFN-stimulated genes (ISGs). Consequently, PLZF-deficient mice had a specific ISG expression defect and as a result were more susceptible to viral infection. This susceptibility correlated with a marked decrease in the expression of the key antiviral mediators and an impaired IFN-mediated induction of natural killer cell function. These results provide new insights into the regulatory mechanisms of IFN signaling and the induction of innate antiviral immunity.

• 出版日期2009-6-19
• 单位河北医科大学; 西北大学