A RAPID, GREEN, AND EFFICIENT MICROWAVE-ASSISTED SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SPIROINDENO[1,2-b]PYRIDO[2,3-d]PYRIMIDINE-5,3 '-INDOLINE DERIVATIVES

作者：Ziarani Ghodsi Mohammadi^*; Hassanzadeh Zahra; Gholamzadeh Parisa; Soorki Ali Abolhassani

来源：Romanian Journal of Chemistry, 2016, 61(2): 77-+.

• green chemistry
• pyridopyrimidine derivatives
• microwave irradiation
• antibacterial properties

A highly efficient microwave-assisted synthesis of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3'-indolines is reported in water media and under catalyst-free condition. Synthesis of these products was developed through one-pot condensation reaction of isatin derivatives, 6-aminouracil and 1,3-indandione compounds under microwave (MW) irradiation. This methodology suggests several benefits including short reaction time, excellent yields of the products, and environmentally benign mild reaction conditions. Additionally, antimicrobial and antifungal properties of the products were investigated.

• 出版日期2016-2