Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea

作者：Tomaszewska Ewa^*; Dobrowolski Piotr; Winiarska Mieczan Anna; Kwiecien Malgorzata; Tomczyk Agnieszka; Muszynski Siemowit; Radzki Radoslaw

来源：Environmental Toxicology and Pharmacology, 2016, 46: 36-44.

DOI：10.1016/j.etap.2016.06.027

• Cadmium
• Lead
• Tea
• Adolescent rats
• Femur geometry
• Mechanical endurance

Adolescent male Wistar rats were used to check whether regular consumption of black, red, white, or green tea would have a protective effect on femur development during 12-week exposure to Cd and Pb (7 mg Cd and 50 mg Pb in 1 kg of the diet). The animals were randomly divided (n = 12) into a positive control (without Cd, Pb and teas), a negative control group (Cd and Pb), and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT). Heavy metals reduced the geometric and densitometric parameters and the total thickness of articular cartilage irrespective of tea administration and influenced mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type. It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action.

• 出版日期2016-9