Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals

作者:Quintard Adrien; Alexakis Alexandre*
来源:Chemical communications, 2011, 47(25): 7212-7214.
DOI:10.1039/c1cc11967b

摘要

An unprecedented intermolecular iminium/enamine Michael addition on enals has been developed by taking advantage of the high reactivity of vinyl sulfones. This powerful organocascade allows for the rapid construction of attractive synthons in high enantioselectivities (typically 99% ee).

  • 出版日期2011