alpha-Azido Bisphosphonates: Synthesis and Nucleotide Analogues

作者：Chamberlain Brian T; Upton Thomas G; Kashemirov Boris A; McKenna Charles E^*

来源：Journal of Organic Chemistry, 2011, 76(12): 5132-5136.

DOI：10.1021/jo200045a

The first examples of alpha-azido bisphosphonates [(RO)(2) P(O)](2)CXN3 (1, R = i-Pr, X = Me; 2, R = i-Pr, X = H; 3, R = H, X = Me; 4, R = H, X = H) and corresponding beta,gamma-CXN3 dGTP (5-6) and alpha/beta-CXN3 dATP (7-8) analogues are described. The individual diastereomers of 7 (7a/b) were obtained by HPLC separation of the dADP synthetic precursor (14a/b).

• 出版日期2011-6-17