Molecular Diagnostics for Head and Neck Pathology

作者：Bilodeau Elizabeth; Alawi Faizan; Costello Bernard J; Prasad Joanne L^*

来源：Oral and Maxillofacial Surgery Clinics of North America, 2010, 22(1): 183-+.

DOI：10.1016/j.coms.2009.10.006

• Head and neck squamous cell carcinoma
• Oral cancer
• Polymerase chain reaction
• Microsatellite instability
• Loss of heterozygosity
• Comparative genomic hybridization
• Proteomics

Molecular diagnostic techniques are quickly finding a role in the detection and diagnosis of tumors, and in predicting their behavior. They may also prove useful in developing new therapeutic approaches to head and neck cancer. The surgeon working in the craniomaxillofacial region should have an understanding of these technologies, their availability in various settings, and how they affect various aspects of treatment, particularly in the detection and treatment of malignancies. This article offers an overview of recent advances in molecular diagnostic techniques, with their implications for diagnosis and management of head and neck tumors.

• 出版日期2010-2