Axonal transcription factors signal retrogradely in lesioned peripheral nerve

作者：Ben Yaakov Keren; Dagan Shachar Y; Segal Ruder Yael; Shalem Ophir; Vuppalanchi Deepika; Willis Dianna E; Yudin Dmitry; Rishal Ida; Rother Franziska; Bader Michael; Blesch Armin; Pilpel Yitzhak; Twiss Jeffery L; Fainzilber Mike^*

来源：The EMBO Journal, 2012, 31(6): 1350-1363.

DOI：10.1038/emboj.2011.494

• axonal transport
• dynein
• importin
• neuronal injury
• STAT

Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral neurons. The involvement of importins in retrograde transport suggests that transcription factors (TFs) might be directly involved in axonal injury signalling. Here, we show that multiple TFs are found in axons and associate with dynein in axoplasm from injured nerve. Biochemical and functional validation for one TF family establishes that axonal STAT3 is locally translated and activated upon injury, and is transported retrogradely with dynein and importin alpha 5 to modulate survival of peripheral sensory neurons after injury. Hence, retrograde transport of TFs from axonal lesion sites provides a direct link between axon and nucleus. The EMBO Journal (2012) 31, 1350-1363. doi: 10.1038/emboj. 2011.494; Published online 13 January 2012

• 出版日期2012-3-21